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New Treatment for Stubborn Gout

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People who suffer from persistent gout that doesn’t respond to first-line drug therapy with xanthine oxidase inhibitors (XOIs) have a new treatment option. The FDA has approved the drug Zurampic (lesinurad) to be used in combination with an XOI, such as allopurinol (Lopurin, Zyloprim) or febuxostat (Uloric), which helps reduce uric acid production.

The buildup of uric acid in the blood—called hyperuricemia—can lead to gout, a form of arthritis characterized by redness, pain and swelling in the joints, and which usually starts in the big toe. The new drug helps the kidney better excrete uric acid, thus reducing buildup. Side effects of Zurampic may include headache, flu- or coldlike symptoms, increased levels of the waste product creatinine in the blood and gastroesophageal reflux disease, or heartburn.

More serious adverse effects in clinical trials included acute kidney failure when Zurampic wasn’t combined with an XOI or when it was used in higher than approved doses. This potential effect is being further evaluated in an additional study required by the FDA. 

 

 

Posted in Digestive Health on March 8, 2016


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